A new study reveals that in people who are depressed or have bipolar disorder, the left hypothalamus was on average 5 percent larger than that of their healthy counterparts.
It has long been known that people more predisposed to depression show a dysregulation of the endogenous stress response system, otherwise known as the hypothalamic-pituitary-adrenal axis (HPA axis), which is normally triggered when we are faced with a stressful situation.
This response increases the amount of cortisol,...
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source https://psychcentral.com/news/2018/09/24/brain-region-involved-with-stress-bigger-in-those-depressed-or-bipolar/138906.html
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